Abstract
Purpose: to analyze and summarize the history of development and application of frameless human mitral allograft (HMA) for atrioventricular heart valve prosthetics (AVCP) from the first experimental studies conducted in the 1960s to the current state of the problem.
Data from Google and PubMed search engines for the queries: “mitral homograft”, “mitral allograft”, “homotransplantations of the mitral valve”, “homograft mitral valve replacement”, etc. has been analyzed.
The authors propose to divide this period of time into 3 periods: the 1st period (from 1962 to 1987) – from the first experimental studies to the development of the method of stentless mitral allograft (SMA) cryopreservation; the 2nd period (from 1987 to 2007) – from the invention of the sparing method of SMA cryopreservation) – from the invention of a gentle method of biotissue cryopreservation and storage to its use in liquid nitrogen with preservation of tissue-forming cells viability to successful application of viable SMA (vSMA) for atrioventricular prosthetics in the clinic; the 3rd period (from 2007 to the present) – improvement of old methods and search for new ways of manufacturing of compound vSMA, their devitalization and subsequent use in the clinic for revitalization.
The pioneer of this direction in cardiac surgery should be considered as F. Robicsek, who in 1962 published the first paper on the prosthesis of the tricuspid valve leaflet with an allogeneic mitral valve leaflet in an experiment. Since then, several more experimental works demonstrating the promising use of SMA have been published; however, the same success could not be repeated in the clinic for a long time, until methods of preserving the biomaterial in an unaltered form were invented.
References
- Akatov V.S., Fesenko N.I., Soloviev V.V., Fadeeva I.E., Chekanov A.V., Muratov R.M. et al. Suppression of calcification of heart valve grafts by devitalizing them. Cell Transplantation and Tissue Engineering. 2010; 5 (1): 41–46 (in Russ.).
- Britikov D.V., Chashchin I.S., Khugaev G.A., Bakuleva N.P. The decellularization of allografts with supercritical carbon dioxide and detergents. Experimental data. The Bulletin of Bakulev Center. Cardiovascular Diseases. 2019; 20 (5): 402–409 (in Russ.). DOI: 10.24022/1810-0694-2019-20-5-402-409
- Heimbecker R.O., Baird R.J., Lajos T.Z., Varga A.T., Greenwood W.F. Homograft replacement of the human mitral valve. A preliminary report. Can. Med. Assoc. J. 1962; 86 (18): 805–809.
- Gulbins H., Kreuzer E., Reichart B. Homografts: a review. Expert Rev. Cardiovasc. Ther. 2003; 1 (4): 533–539. DOI: 10.1586/14779072.1.4.533
- Akatov V.S., Ryndina N.I., Muratov R.M., Santalova I.M., Soloviev V.V., Britikov D.V. et al. Participation of mitochondria in the initiation of calcification in heart valve grafts and vessels. Reports of the Academy of Sciences. 2006; 406 (6): 832–834 (in Russ.).
- Carpentier A., Blondeau P., Laurens P., Mancel P., Laurent D., Dubost C. Remplacement des valvules mitrales et tricuspides par des hétérogreffes [Replacement of mitral and tricuspid valves by heterografts]. Ann. Chir. Thorac. Cardiovasc. 1968; 7 (1): 33–38.
- Boсkeria L.A., Podzolkov V.P., Astrakhantseva T.O., Kokshenev I.V., Britikov D.V., Fadeev A.A. et al. Results of congenital heart diseases correction by means of bioprostheses from Glisson’s bovine capsule. Russian Journal of Thoracic and Cardiovascular Surgery. 2018; 60 (1): 44–54 (in Russ.). DOI: 10.24022/0236-2791-2018-60-1-44-54
- Bockeria L., Sabirov B., Zaets S. et al. Experience with a new biological valve: early and midterm results. In: Abstracts of the third World Congress on Heart Disease. 2003, Jul. 13–15; USA. Washington, DC; 2003.
- Senning Å. Rekonstruktion der Mitralklappe: Homoioplastik [Reconstruction of the mitral valve: homoplasty]. Thoraxchir. Vask. Chir. 1968; 16 (6): 601–605. DOI: 10.1055/s-0028-1100585
- O'Brien M.F., Stafford G., Gardner M., Pohlner P., McGiffin D., Johnston N. et al. The viable cryopreserved allograft aortic valve. J. Card. Surg. 1987; 2 (1 Suppl.): 153–167. DOI: 10.1111/jocs.1987.2.1s.153
- Acar C., Tolan M., Berrebi A., Gaer J., Gouezo R., Marchix T. et al. Homograft replacement of the mitral valve. Graft selection, technique of implantation, and results in forty-three patients. J. Thorac. Cardiovasc. Surg. 1996; 111 (2): 367–380. DOI: 10.1016/s0022- 5223(96)70446-4
- Tsaregorodtsev A.V., Savelieva Yu.D., Shorina K.N. Using of the mitral valve for atrioventricular heart valve prosthesis. The Bulletin of Bakulev Center. Cardiovascular Diseases. 2023; 24 (3): 178 (in Russ.).
- Lam C.R., Aram H.H., Munnell E.R. An experimental study of aortic valve homografts. Surg. Gynecol. Obstet. 1952; 94 (2): 129–135.
- O'Brien M.F., Gerbode F. Homotransplantation of the mitral valve. Preliminary experimental report and review of literature. Aust. N. Z. J. Surg. 1964; 34: 81–88. DOI: 10.1111/j.1445-2197.1964.tb06204.x
- Coustou F., Crockett R., Fontan F., Dubourg G., Dulong de Rosnay H. Homogreffes valvulaires aortiques. Organisation d'une banque [Aortic valve homografts. Organization of a bank]. Ann. Chir. Thorac. Cardiovasc. 1968; 7 (2): 539–541.
- Verghese S., Padmaja P., Sindhu B., Elizabeth S.J., Lesley N., Cherian K.M. Homograft valve bank: our experience in valve banking. Indian Heart J. 2004; 56 (4): 299–306.
- Kumar A.S., Choudhary S.K., Mathur A., Saxena A., Roy R., Chopra P. Homograft mitral valve replacement: five years' results. J. Thorac. Cardiovasc. Surg. 2000; 120 (3): 450–458. DOI: 10.1067/mtc.2000.107829
- Plunkett M.D., Schneider D.J., Shah J.J., Bash S.E., Bond L.M., Geiss D.M. Homograft replacement of mitral valve in children. Ann. Thorac. Surg. 1998; 66 (3): 849–852. DOI: 10.1016/s0003-4975(98)00645-6
- Reardon M.J., Vinnerkvist A., LeMaire S.A. Mitral valve homograft for mitral valve replacement in acute bacterial endocarditis. J. Heart Valve Dis. 1999; 8 (1): 71–73.
- Khanna S.K., Ross J.K., Monro J.L. Homograft aortic valve replacement – seven years’ experience with antibiotic-treated valves. Thorax. 1981; 36 (5): 330–337. DOI: 10.1136/thx.36.5.330 21. Robicsek F., Sanger P.W., Taylor F.H., Robicsek L. Transplantability of heart valves. Arch. Surg. 1962; 84: 141–148. DOI: 10.1001/archsurg.1962.01300190145018
- Cachera J.P., Salvatore L., Hermant J., Herbinet B. Reconstructions plastiques de l'appareil mitral chez le chien au moyen de valves mitrales homologues conserv'ees (rapport pr'eliminaire) [plastic reconstruction of the mitral apparatus in dogs by means of preserved homologous mitral valves (preliminary report)]. Ann. Chir. Thorac. Cardiovasc. 1964; 3: 494–501.
- Rastelli G.C., Berghuis J., Swan H.J. Evaluation of function of mitral valve after homotransplantation in the dog. J. Thorac. Cardiovasc. Surg. 1965; 49: 459–474.
- Vanvliet P.D., Titus J.L., Berghuis J., Ellis F.H. Jr. Morphologic features of homotransplanted canine mitral valves. J. Thorac. Cardiovasc. Surg. 1965; 49: 504–510.
- Hubka M., Siska K., Brozman M., Holec V. Replacement of mitral and tricuspid valves by mitral homograft. J. Thorac. Cardiovasc. Surg. 1966; 51 (2): 195–204.
- Bernhard A., Largiadèr F., Senning Å. 138. Homologe Mitralklappentransplantation [138. Homologous mitral valve transplantation]. Langenbecks Arch. Chir. 1967; 319: 816–819. German. DOI: 10.1007/BF02659385
- Malm J.R., Bowman F.O. Jr, Harris P.D., Kowalik A.T. An evaluation of aortic valve homografts sterilized by electron beam energy. J. Thorac. Cardiovasc. Surg. 1967; 54 (4): 471–477.
- Largiadèr F., Senning Å., Träbert E., Rosenmund H. Erfassung der Abstossung von Herzhomotransplantaten [Diagnosis of cardiac homograft rejection]. Helv. Chir. Acta. 1969; 36 (3): 289–295.
- Huber R., Rothlin M., Senning Å. Spätresultate nach Atrioventrikulärklappenersatz mit Mitralallotransplantat [Late results of replacement of the antrio-ventricular valve]. Thoraxchir. Vask. Chir. 1975; 23 (1): 33–38. DOI: 10.1055/s-0028-1096923
- Ross D.N. Homograft replacement of the aortic valve. J. Cardiovasc. Surg. (Torino). 1965; 5 (6), Suppl.: 89–94.
- Babenko S.I., Muratov R.M., Sorkomov M.N. Current trends in the creation of cell-free allo- and xenotissues for reconstruction of heart structures. Russian Journal of Transplantology and Artificial Organs. 2021; 23 (1): 150–156 (in Russ.). DOI:10.15825/1995-1191-2021-1-150-156
- Livi U., Abdulla A.K., Parker R., Olsen E.J., Ross D.N. Viability and morphology of aortic and pulmonary homografts. A comparative study. J. Thorac. Cardiovasc. Surg. 1987; 93 (5): 755–760.
- Sievers H.H., Lange P.E., Yankah A.C., Wessel A., Bernhard A. Allogeneous transplantation of the mitral valve. An open question. Thorac. Cardiovasc. Surg. 1985; 33 (4): 227–229. DOI: 10.1055/s-2007-1014126
- Levy R.J. Glutaraldehyde and the calcification mechanism of bioprosthetic heart valves. J. Heart Valve Dis. 1994; 3 (1): 101–104.
- Gall K.L., Smith S.E., Willmette C.A., O'Brien M.F. Allograft heart valve viability and valve-processing variables. Ann. Thorac. Surg. 1998; 65 (4): 1032–1038. DOI: 10.1016/s0003-4975(98)00085-x
- Watts L.K., Duffy P., Field R.B., Stafford E.G., O'Brien M.F. Establishment of a viable homograft cardiac valve bank: a rapid method of determining homograft viability. Ann. Thorac. Surg. 1976; 21 (3): 230–236. DOI: 10.1016/s0003-4975(10)64297-x
About the authors
- Leo A. Bockeria, Academician of the Russian Academy of Sciences, President of Center; ORCID
- Anton V. Tsaregorodtsev, Student; ORCID
- Dmitriy V. Britikov, Dr. Med. Sci., Leading Researcher; ORCID
- Sergey P. Glyantsev, Dr. Med. Sci., Professor, Chief Researcher; ORCID
