Abstract
Background. Stentless prostheses are a variant of medical devices for the treatment of valvular heart disease, which, due to their design, provides high hemodynamic efficiency and biomechanics similar to native ones.
The aim of the work was an in vitro study of the quantitative hydrodynamic characteristics of a line of commercial stentless aortic valve prostheses.
Material and methods. In this work, we studied 12 specimens of stentless aortic valve bioprostheses “TiAra” (“NeoKor”, Kemerovo), represented by four standard sizes (19, 21, 23, 25 mm of landing diameter). The hydrodynamic characteristics were evaluated in a Vivitro Pulse duplicator test bench (Vivitro Labs, Canada) while simulating the physiological regime of blood flow. Additionally, the operation of the leaflet apparatus of each prosthesis was recorded by high-speed video recording using a Fastvideo-250 camera (Fastvideo, Russia).
Results. The study showed that all the presented models of bioprostheses have sufficient quantitative performance characteristics, expressed in the effective area of the hole (1.3–2.1 cm2 ), low transprosthetic gradient (4.0–8.5 mmHg), small the total volume of regurgitation (4.5–7.8 ml/cycle). In addition, it was shown that the elements of a stentless prosthesis move in accordance with the cardiac cycle, reducing the diameter of the prosthesis in diastole by 3.8–4.6%, depending on the size, due to such biomechanics. Additionally, we demonstrate the relationship between a number of hydrodynamic characteristics and the diameter of the prosthesis, which can be taken into account at the stage of preoperative planning.
Conclusion. The stentless aortic valve bioprosthesis “TiAra” demonstrates high quantitative hydrodynamic characteristics, as well as biomechanics that ensure the mobility of its elements – commissural struts, during the cardiac cycle in accordance with the movements of the aortic root.
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About the authors
- Kirill Yu. Klyshnikov, Cand. Med. Sci., Researcher of Laboratories of New Biomaterials; ORCID
- Evgeniy A. Ovcharenko, Cand. Tech. Sci., Head of the Laboratory of New Biomaterials; ORCID
- Aleksey V. Evtushenko, Dr. Med. Sci., Head of the Laboratory of Heart Diseases; ORCID
- Leonid S. Barbarash, Academician of the Russian Academy of Sciences, Chief Researcher; ORCID
