Refractory angina pectoris – definition of the term, pathophysiological features of the disease

Authors: Bockeria L.A., Donakanyan S.A., Biniashvili M.B., Shvartz V.A., Petrosyan A.D., Le T.G.

Company: Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

UDC: 616.12-009.72
DOI: https://doi.org/10.24022/1810-0694-2023-24-4-295-302

Cite as: Bockeria L.A., Donakanyan S.A., Biniashvili M.B., Shvartz V.A., Petrosyan A.D., Le T.G. Refractory angina pectoris – definition of the term, pathophysiological features of the disease. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2023; 24 (4): 295–302 (in Russ.). DOI: 10.24022/1810-0694-2023-24-4-295-302

Received / Accepted: 03.07.2023 / 08.08.2023

Keywords: angina pectoris refractory angina pectoris coronary heart disease myocardial ischemia pathophysiology

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Abstract

In patients who are diagnosed with refractory angina pectoris, the use of optimal therapy regimens, as a rule, does not lead to a positive result, such patients are accompanied by a constant feeling of incapacity and persistent angina attacks. The study of the mechanisms of myocardial ischemia and the pathways linking ischemia with the subjective perception of angina indicates a complex model of interactions between the heart and the brain in creating the symptoms of the disease. Violation of these mechanisms may be of particular importance in refractory angina pectoris, as it may cause a suboptimal response to traditional anti-ischemic drugs in this population. This article reviews the pathophysiological mechanisms of pain symptoms in angina pectoris, because an understanding of the causes of angina attacks will help improve the quality of life of such patients.

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About the authors

Leo A. Bockeria, Academician of the Russian Academy of Sciences, President of the Center; ORCID
Sergey A. Donakanyan, Dr. Med. Sci., Head of Department, Cardiovascular Surgeon; ORCID
Mikhail B. Biniashvili, Cand. Med. Sci., Leading Researcher, Deputy Director, Cardiovascular Surgeon; ORCID
Vladimir A. Shvartz, Dr. Med. Sci., Leading Researcher; ORCID
Andrey D. Petrosyan, Cand. Med. Sci., Junior Researcher, Cardiovascular Surgeon; ORCID
Tatyana G. Le, Junior Researcher, Cardiovascular Surgeon; ORCID

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Chief Editor

Elena Z. Golukhova, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, Director of Bakoulev National Medical Research Center for Cardiovascular Surgery

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