Abstract
Introduction. Irrational use of antimicrobial agents results in occurrence of significant side effects
and growth of economic costs. Maintenance of the effective use of antibiotics is the essential part
of high-quality clinical practice. The aim of the study was to assess the efficiency of administrative
control over antibiotic application in a cardiosurgical clinic with restrictions in delivery of
such group of agents into the wards in terms of authorization in medical disposals.
Methods. ABC and ATC/DDD comparative analyses of antibiotic management in adults were
performed before and after introduction of administrative control system (May 2010 - April
2011 and May 2011 - April 2012, respectively). Infectious complication rates were also assessed.
Results. As compared to the first period, the reduction of total score for application of antibacterial
and antifungal agents was noted after introduction of restrictive policy. The rates reduced
from 85.2 to 68.7 DDDs on 100 patient-days (according to the most cost-based group A - 42.4
to 30.8 DDDs - by 1.4 times, according to group B - from 13 to 11.8 DDDs - by 1.1 times).
Infectious-septic complications rate did not change significantly in the immediate postoperative
period and was 1.5 and 1.7%, respectively (p = 0.3).
Conclusion. Authorization practice for prescribed antimicrobial agents by physicians is the effective
tool for optimization of their application.
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