Abstract
The article presents a description of a clinical case with an analysis of the causes of adverse results of percutaneous
coronary intervention (PCI), showing the role of endothelial dysfunction, and in particular, the endothelin system,
its genetic polymorphism. The significant role of the endothelin system, its genetic polymorphism (carriage of the
AA genotype AA ENDRA rs1801708 and the genotype CC EDN1 rs5370) and endothelial dysfunction in the mechanisms
of development and progression of the atherosclerotic process, their influence on the results of PCI in patients
with CHD have been shown. This observation shows that genetic testing methods need to be brought closer to clinical
practice. Genotyping of the polymorphic site of the endothelin receptor type A gene (ENDRA rs1801708) can
help in predicting the risk of negative PCI results. For carriers of the AA ENDRA rs1801708 genotype, who are at
high risk of developing stent restenosis and progression of coronary atherosclerosis, it is necessary to carry out more
“tough” measures of secondary prevention of coronary heart disease, including correction measures for increasing
expression of the ENDRA receptors (quitting smoking, correcting hypertension with achieving optimal values of
arterial pressure, correction of diabetes therapy, lipid-lowering therapy with the achievement of the target values of
the lipid spectrum). It is advisable to include in therapy drugs that affect the function of the vascular endothelium
(calcium antagonists, angiotensin converting enzyme inhibitors).
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DOI: 10.1097/MD.0000000000012372
About the authors
- Yuriy I. Buziashvili, Dr. Med. Sc., Professor, Academician of the Russian Academy of Sciences, Head of Department, orcid.org/0000-001-7016-7541
-
Inna V. Koksheneva, Dr. Med. Sc., Senior Researcher, orcid.org/0000-0002-8797-9340
-
Karen V. Petrosyan, Cand. Med. Sc., Head of Department, orcid.org/0000-0002-3370-0295
-
Il'ya A. Inauri, Junior Researcher;
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El'vina F. Tugeeva, Dr. Med. Sc., Senior Researcher, orcid.org/0000-0003-1751-4924
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Igor' P. Shuvaev, Cand. Med. Sc., Cardiologist, orcid.org/0000-0003-1242-687Х
-
Mayа B. Usherzon, Cand. Med. Sc., Researcher
