State of the problem of increasing the thromboresistance of artificial materials and products intended for contact with blood in Bakoulev National Medical Research Center for Cardiovascular Surgery

Company: Bakoulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

UDC: 616.12-77:616-005.6(НМИЦССХ им. А.Н. Бакулева):615.46
DOI: https://doi.org/10.24022/1810-0694-2019-20-11-12-904-922

Cite as: Novikova S.P. State of the problem of increasing the thromboresistance of artificial materials and products intended for contact with blood in Bakoulev National Medical Research Center for Cardiovascular Surgery. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2019; 20 (11–12): 904–22 (in Russ.). DOI: 10.24022/1810-0694-2019-20-11-12-904-922

Received / Accepted: 16.09.2019 Принята к печати 20.09.2019

Keywords: thromboresistance, biocompatibility, modification, blood vessel prostheses, artificial heart valves implantable products

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Abstract

The stages of the progressive solution to the problem of giving thromboresistant and other necessary properties are given: minimal surgical porosity, antimicrobial properties, optimal strength characteristics of materials and implantable products developed and currently used in cardiovascular surgery. An assessment of previous work is given. The role of materials, product design, hemodynamic parameters of blood flow in prostheses of blood vessels and artificial heart valves is indicated. Since the reason for the formation of blood clots on the surface of foreign materials has not yet been clarified in detail, a truly thromboresistant material has not yet been created. However, there are attempts to take into account an increasing number of different factors affecting thrombosis. Tissue engineering, cell technology and other biotechnology techniques can provide new options for scientific research. Various methods for evaluating the effectiveness of materials modification methods are considered. It is shown that to create the most promising materials it is advisable to conduct complex biomedical tests in vitro, ex vivo, in vivo. The experimentally confirmed positive results of in vivo modified prostheses of blood vessels, cuffs for artificial heart valves and other products for clinical use are presented. In the Bakoulev National Medical Research Center for Cardiovascular Surgery organized a small-scale production of blood vessel prostheses, cardiac surgical patches with a coating of «BASEX», «BASEX-SP», «BASEX-Patch».

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About the authors

Svetlana P. Novikova, Dr. of Biology, Professor, Head of Laboratory, orcid.org/0000-0001-7860-7388

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Chief Editor

Elena Z. Golukhova, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, Director of Bakoulev National Medical Research Center for Cardiovascular Surgery

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