Abstract
The review highlights key issues in the scientific and practical activities of the nuclear medicine department at the Bakoulev National Medical Research Center for Cardiovascular Surgery. The brief historical background contains information about the main stages of the department's formation, provides a rationale for the main activities on the basis of an actively developing PET-center. The main attention is paid to the study and implementation of diagnostic methods for coronary artery disease and infectious inflammatory processes in the heart after surgery. The importance of quantitative assessment of blood flow as a method of obtaining important additional information in the examination of myocardial perfusion by positron emission tomography/computed tomography (PET/CT) with 13Nammonium, especially in multivessel coronary artery disease, has been substantiated. The emphasis is made on the features of blood flow in stenoses of various grades. The questions of the influence of microvascular dysfunction on blood flow in the presence of widespread atherosclerosis are discussed. An analysis of the use of PET/CT with 18Ffluorodeoxyglucose in the diagnosis of inflammation indicates a high sensitivity and specificity in determining changes in paraprosthetic endocarditis of heart valves and vascular prostheses, as well as in infection of intravascular implanted devices. The role of PET/CT in the diagnosis, assessment of the true prevalence of the process and in the correction of treatment tactics is shown. From the presented data, it follows that it is advisable to further develop the selected directions of the department's activities.
References
- Bockeria L.A. Aslanidis I.P., Vakhromeeva M.N., Shurupova I.V., Ryumina E.N., Berishvili I.I. et al. Myocardial 201Tl and 99mTc single-photon emission computed tomoscintigraphy in the diagnosis of stenosing lesions of the coronary arteries. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2002; 3 (7): 70–8. (in Russ.).
- Shurupova I.V., Rogova T.V., Aslanidis I.P., Serov T.V., Shavman M.G. PET myocardial in the child with Bland–White–Garland syndrome: diagnosis of scar and reversible ischemic changesin the left ventricle. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2014; 15 (2): 44–50 (in Russ.).
- Boсkeria L.A., Aslanidis I.P., Shurupova I.V., Chernova A.A. Significance of the hybrid PET/CT myocardium with ctca during examination patients with cad verified and prospective. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2016; 17 (4): 4–11 (in Russ.).
- Boсkeria L.A., Aslanidis I.P., Mukhortova O.V., Shurupova I.V., Derevyanko E.P., Sil’chenkov A.V. et al. Positron emission tomography: possibilities of clinical application in cardiology, oncology and neurology. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2009; 10 (1): 12–26 (in Russ.).
- Aslanidis I.P., Shurupova I.V., Chernova A.A., Kotlyarov A.A., Perepelov A.V. Myocardial 13N-ammonia positron emission tomography, combined with multispiral computed tomography of the heart, in the examination of patients with verified and suspected coronary heart disease: Educational and methodological recommendations. Moscow; 2018 (in Russ.).
- Boсkeria L.A., Aslanidis I.P., Shavman M.G., Shurupova I.V., Trifonova T.A., Ekaeva I.V. Diagnostic performance of quantitative 13N-ammonia PET/CT measures of myocardial blood flow and coronary flow reserve for the assessment of functional significance of coronary stenosis. Creative Cardiology. 2019; 13 (1): 17–27. DOI: 10.24022/1997-3187-2019-13-1-17-27 (in Russ.).
- van Nunen L.X., Zimmermann F.M., Tonino P.A.L., Barbato E., Baumbach A., Engstro/m Th. et al. Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial. Lancet. 2015; 386(10006): 1853–60. DOI: 10.1016/S0140-6736(15)00057-4
- Boden W.E., O'Rourke R.A., Teo K.K., Hartigan P.M., Maron D.J., Kostuk W.J. et al. COURAGE Trial Research Group optimal medical therapy with or without PCI for stable coronary disease. N. Engl. J. Med. 2007; 356 (15): 1503–16. DOI: 10.1056/NEJMoa070829
- Boсkeria L.A., Aslanidis I.P., Shurupova I.V., Shavman M.G., Derevyanko E.P., Ekaeva I.V. et al. Quantitative noninvasive assessment of myocardial blood flow and coronary flow reserve using dynamic 13N-ammonia stress-PET/CT for the detection of the functional significance of coronary stenosis. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2017; 18 (5): 489–500. DOI: 10.24022/1810-0694-2017-18-5-489-500 (in Russ.).
- Oikonomou E., Siasos G., Tsigkou V., Bletsa E., Panoilia M.E., Oikonomou I.N. et al. Coronary artery disease and endothelial dysfunction: Novel diagnostic and therapeutic approaches. Curr. Med. Chem. 2020; 27 (7): 1052–80. DOI: 10.2174/0929867326666190830103219
- Erba A.P., Pizzi M.N., Roque A., Salaun E., Lancellotti P., Tornos P. et al. Multimodality imaging in infective endocarditis an imaging team within the endocarditis team. Circulation. 2019; 140: 1753–65. DOI: 10.1161/CIRCULATIONAHA.119.040228
- Aslanidis I.P., Pursanova D.M., Mukhortova O.V., Shurupova I.V., Ekaeva I.V., Serguladze S.U. et al. Role of 18F-fluorodeoxyglucose PET/CT in patients with suspected infective processes in heart and vessels after cardiac surgeries. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2019; 20 (11–12): 1070–7. DOI: 10.24022/1810-0694-2019-20-11-121070-1077 (in Russ.).
- Boсkeria L.A., Aslanidis I.P., Pursanova D. M., Mukhortova O.V., Shurupova I.V., Ekaeva I.V., et al. Features 18F-fluorodeoxyglucose PET/CT in the diagnosis of infectious processes associated with implanted intracardiac devices. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2019; 20 (6): 498–508. DOI: 10.24.022/1810-0694-2019-20-6-498-508 (in Russ.).
- Boсkeria L.A., Aslanidis I.P., Pursanova D. M., Mukhortova O.V., Shurupova I.V., Katunina T.A. et al. Positron emission tomography combined with computed tomography in patients with suspected cardiac implantable electronic device infection. Annals of Surgery. 2019; 24 (3): 189–197. DOI:10.24022/1560- 9502-2019-24-3-189-197 (in Russ.).
- Golukhova E.Z., Aslanidis I.P., Pursanova D.M., Mukhortova O.V., Shurupova I.V., Katunina T.A. et al. Positron emission tomography combined with computed tomography with 18F-fluorodeoxyglucose in assessing the prevalence of the infectious process in patients with suspected infectious endocarditis of the prosthetic valve. Creative cardiology. 2020; 14 (3): 245–4. DOI: 10.24022/1997-3187-2020-14-3-245-254 (in Russ.).
- Ashrafyan L.A., Aslanidis I.P., Mukhortova O.V., Shurupova I.V., Derevyanko E.P., Katunina T.A. et al. Possibilities of positron emission tomography in the diagnosis of primary and recurrent ovarian cancer: a review of literature. Tumors of the Female Reproductive System. 2012; 1: 75–83. DOI: 10.17650/1994-4098-2012-0-1- 75-82 (in Russ.).
- Mukhortova O.V., Aslanidis I.P., Shurupova I.V., Derevyanko E.P., Katunina T.A., Poddubnaya I.V. et al. Positron emission tomography for assessment of bone marrow involvement in patients with malignant lymphomas. Medical Radiology and Radiation Safety. 2010; 55 (2): 43–52 (in Russ.).
About the authors
- Irakliy P. Aslanidis, Dr. Med. Sc., Professor, Head of Department, ORCID
- Irina V. Shurupova, Dr. Med. Sc., Senior Researcher,ORCID
- Ol’ga V. Mukhortova, Dr. Med. Sc., Senior Researcher, ORCID
- Tat’yana A. Trifonova, Cand. Med. Sc., Head of Laboratory, ORCID
- Diana M. Pursanova, Cand. Med. Sc., Senior Researcher,ORCID
- Margarita G. Shavman, Cand. Med. Sc., Researcher, ORCID
