Main aspects of human albumin use in intensive care of pediatric cardiosurgical patients

Authors: Bockeria L.A., Beketovskiy V.Yu., Manerova A.F.

Company: Vyacheslav Yu. Beketovskiy, E-mail: slava_doctor@mail.ru

UDC: 612.382.4:612.398.131:616.12-083.98-089
DOI: https://doi.org/10.24022/1810-0694-2021-22-3-325-331

Cite as: Bockeria L.A., Beketovskiy V.Yu., Manerova A.F. Main aspects of human albumin use in intensive care of pediatric cardiosurgical patients. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2021; 22 (3): 325–31 (in Russ.). DOI: 10.24022/1810-0694-2021-22-3-325-331

Received / Accepted: 01.06.2021 / 04.06.2021

Keywords: plasma proteins albumin hypoalbuminemia transcapillary leak indications for use postoperative complications mortality clinical guidelines

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Abstract

Human albumin is a physiological plasma expanding solution. Certain limitations and high cost of it use in presence of alternative therapeutic approaches, such as crystalloid and non-protein colloid solutions, are indicating the need of clear and substantiate guidelines for clinical use of human albumin. Absence of such guidelines has driven a number of researches with quite controversial results. Human albumin is widely used in pediatric cardiac surgery and intensive care. Numerous studies indicate on unfounded use of albumin solutions due to the lack of comprehensive clinical guidelines for the use of human albumin in pediatric intensive care. Many studies that have been conducted in a cohort of adult patients, try to extrapolate their results on to pediatric patients. However, significant differences in the anatomical and physiological characteristics do not allow to use adult clinical guidelines in pediatric practice without appropriate processing and adaptation of the entire information pool. Therefore, the aim of this review is to determine the place of human albumin in the clinical setting of intensive care in pediatric cardiac surgery.

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About the authors

Leo A. Bockeria, Academician of RAS and RAMS, President, ORCID
Vyacheslav Yu. Beketovskiy, Head of Department, ORCID
Asya F. Manerova, Cand. Med. Sc., Anestesiologist-Intensivist, ORCID

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Chief Editor

Elena Z. Golukhova, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, Director of Bakoulev National Medical Research Center for Cardiovascular Surgery

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