Аннотация
Человеческий альбумин является физиологическим плазмоэкспандером. Ограниченная применимость и высокая стоимость растворов альбумина при наличии альтернативных терапевтических подходов, включая использование кристаллоидов и непротеиновых коллоидов, диктуют необходимость в четких и обоснованных рекомендациях для его применения. Их отсутствие послужило предпосылкой для многочисленных исследований, результаты которых в ряде случаев оказались достаточно противоречивыми. Человеческий альбумин имеет широкое применение в педиатрической кардиохирургии и интенсивной терапии. Многочисленные исследования свидетельствуют о зачастую необоснованном применении растворов альбумина ввиду отсутствия полноценных клинических рекомендаций по применению человеческого альбумина в педиатрической интенсивной терапии. Многие исследования проводились в популяции взрослых пациентов с экстраполяцией результатов на педиатрических пациентов. Однако значимые различия в анатомо-физиологических особенностях не дают возможности использования клинических рекомендаций для взрослых в педиатрической практике без соответствующей обработки и адаптации всего информационного пула. Поэтому целью данного обзора является определение места человеческого альбумина в практике интенсивной терапии в педиатрической кардиохирургии.
Литература
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Об авторах
- Бокерия Лео Антонович, академик РАН и РАМН, президент, ORCID
- Бекетовский Вячеслав Юрьевич, заведующий отделением реанимации и интенсивной терапии для недоношенных и детей раннего возраста с ВПС (до 3 лет), ORCID
- Манерова Ася Фароковна, канд. мед. наук, врач – анестезиолог-реаниматолог, ORCID
