Abstract
Introduction. The problem of giving the necessary functional properties to products in contact with blood (vascular prostheses, cardiac surgical patches, cuffs of artificial heart valves, stent grafts, conduits, catheters, hemodialyzers etc.) remains actual: thromboresistance, antimicrobial properties, tightness, optimal strength characteristics. Postoperative adhesions also remain an unsolved problem in surgery. The most effective can be biodegradable products in the form of films/plates/membranes, while the maximum effect can be reached by immobilizing drugs that enhance the anti-adhesion effect into the film composition. In Russia there are no domestic anti-adhesive materials in the form of biodegradable films/plates, including for the prevention of adhesions in the pericardial cavity.
The aim of research – development of optimal modification technologies for improving the functional properties of medical devices for contact with blood and the internal environment of the body (anti-adhesion materials).
Material and methods. The objects of modification are work pieces of textile and non-textile medical products: vascular prostheses, cardiac surgical patches, cuffs of artificial heart valves, stent grafts, conduits, hemodialysis circuits. Modifying components: drugs with antiaggregatory, anticoagulant, antimicrobial, anti-inflammatory, antioxidant properties; gelatin of JSC “Mozhelit”; cross-linking agent is glutaraldehyde; plasticizer is glycerin. Sterilization made by ethylene oxide at 37 °C. Were assessed the secretion of drugs from the polymer matrix, time of degradation, strength characteristics, interaction of samples with native blood, microbiological characteristics. Experimental studies were conducted in vivo on small and large animals.
Results. The laboratory develops innovative technologies for obtaining and applying bioactive multilayer coatings to the surface of various products for contact with blood in order to give the products the necessary properties. On the basis of these technologies blood vessel prostheses “BASEKS”, “BASEKS-SP”, cardiac surgical patches “BASEKSPatch” with a complex of properties are serially produced for clinical use. No other company produces products with a set of necessary properties. Artificial heart valve cuffs, conduits, stent grafts and hemodialysis circuits are modified. The first in Russia biodegradable films/porous plates “ANTISPAY-LAB”, “ANTISPAY-LAB M” are being developed for the prevention of adhesions based on gelatin, including drugs from natural raw materials that enhance the anti-adhesion effect (colchicine, rotocan, propolis, heparin).
Conclusion. The developed technologies are competitive and patentable in terms of quality, functional, economic efficiency, and the level of innovation.
References
- Bockeria L.A., Novikova S.P. Blood vessel prostheses and cardiosurgical patches with thromboresistant, antimicrobial properties and zero surgical porosity. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2008; 9 (4): 5–20 (in Russ.).
- Novikova S.P. State of the problem of increasing the thromboresistance of artificial materials and products intended for contact with blood in Bakoulev National Medical Research Center for Cardiovascular Surgery. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2019; 20 (11–12): 904–22 (in Russ.). DOI: 10.24022/ 1810-0694-2019-20-11-12-904-922
- Park H., Baek S., Kang H., Lee D. Biomaterials to prevent post-operative adhesion. Materials (Basel). 2020; 13 (14): 3056–81. DOI: 10.3390/ma13143056
- Bockeria L.A., Abdulgasanov R.A., Arakelyan V.S., Novikova S.P., Rakhimov A.A., Gamzaev N.R. et al. Indigenously developed vascular explants and patches "BASEX" in reconstructive сardiovascular surgery (results of 3600 operations). Russian Journal of Thoracic and Cardiovascular Surgery. 2014; 2: 21–7 (in Russ.).
- Abdulgasanov R.A., Bockeria L.A., Novikova S.P., Abdulgasanova M.R., Gazimagomedov Z.I., Galustov D.V. et al. Domestic explants BASEKS in reconstructive surgery of aorta and magistral arteries. Complex Issues of Cardiovascular Diseases. 2016; (3): 69–74 (in Russ.). DOI: 10.17802/2306-1278-2016-3-69-74
- Bockeria L.A., Bockeria O.L., Sivtsev V.S., Novikova S.P., Salokhedinova R.R., Nikolashina L.N. et al. Experimental evaluation of the biodegradable film compositions based on gelatin with colchicine. The Bulletin of Experimental Biology and Medicine. 2016; 161 (3): 394–8 (in Russ.).
- Bockeria L.A., Bockeria O.L., Biniashvili M.B., Donakanyan S.A., Novikova S.P., Salokhedinova R.R. et al. In vivo evaluation of the bioresorbable polymeric compositions “ANTISPAY-LAB”, “ANTISPAY-LAB M” for the prevention of adhesions complications in the experiment. The Annals of Surgery. 2018; 5: 299–313 (in Russ.). DOI: 10.18821/1560-9502-2018-23-5-299-313
- Bockeria L.A., Novikova S.P., Bockeria O.L., Kostrov V.I., Salokhedinova R.R., Nikolashina L.N. et al. The film compositions based on gelatin structured by different ways. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2014; 15 (4): 60–72 (in Russ.).
- Abramyan M.V., Yarustovsky M.B., Novikova S.P., Komardina E.V., Rogal’skaya E.A., Nazarova E.I. Extracorporeal therapy in patients at high risk of bleeding. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2019; 20 (11, appl.): 157 (in Russ.).
About the authors
- Svetlana P. Novikova, Dr. Biol. Sci., Professor, Head of the Laboratory; ORCID
- Regina R. Salokhedinova, Cand. Econ. Sci., Researcher; ORCID
- Natal’ya V. Nizova, Leading Technologist
- Aleksandra A. Orlova, Cand. Chem. Sci., Leading Technologist
- Valeriy S. Arakelyan, Dr. Med. Sci., Professor, Head of Department; ORCID
- Vasiliy G. Papitashvili, Cand. Med. Sci., Leading Researcher, Cardiovascular Surgeon; ORCID
- Vladimir A. Mironenko, Dr. Med. Sci., Head of Department, Cardiovascular Surgeon; ORCID
- Sergey V. Garmanov, Cand. Med. Sci., Cardiovascular Surgeon; ORCID
- Mikhail M. Alshibaya, Dr. Med. Sci., Professor, Head of Department; ORCID
- Ravil’ M. Muratov, Dr. Med. Sci., Professor, Head of Department; ORCID
- Leo A. Bockeria, Academician of the RAS and RAMS, President; ORCID
- Elena Z. Golukhova, Dr. Med. Sci., Professor, Academician of the RAS, Director; ORCID
