Abstract
Objective. At present thanks to hybrid technologies, simultaneous assessment of calcification of calcification and perfusion
of LV myocardium has become possible. In this regard the issues related to possibility to combine both the
diagnostic and prognostic potential of the anatomical and functional parameters of the coronary arteries according
to the stress-PET/CT scan data become of current interest.
Material and methods. 63 patients (34 men) aged 34 to 82 (60.6±10.2) years underwent stress – PET/CT with
13N-ammonium and simultaneously CaSc-СТ on a hybrid scanner Biograph-64. Patients were divided into 4 groups
depending on the value of CaSc: group 1 (n=28) – CaSc within 0–10; 2nd group (n=9) – with moderate CaSc
(11–100), 3rd (n=6) – with a mean CaSc of 101–400; 4th group (n=20) – with CaSc>400. A semi-quantitative
assessment of perfusion included the determination of the Summed Stress Score (SSS).
Results. The degree of myocardial perfusion disorder is compared with the magnitude of CaSc. In the group with
CaSc>400 perfusion defects are more common (80% patients) than in groups with lower CaSc: 18, 11 and 16% of
patients in 1, 2 and 3 groups, respectively. Comparison of groups by the value of SSS showed that in group 1 SSS
was 2.5 [0; 4.0], in the 2nd group – 2.0 [1.5; 3.0], in the 3rd group – 2.5 [1.7; 4.2] and in the CaSc group > 400 –
9.0 [4.25; 20.0] (p≤0.05). There was a moderate correlation between SSS and CaSc (r=0.55, p<0.024).
Conclusion. A significant relationship was found between the magnitude of CaSc and the degree of stress-perfusion
failure. Survival analysis has shown the possibility of improving risk stratification in the complex use of anatomical
information on the status of SC and the physiological characteristics obtained by perfusion stress-scanning. These
observations allow us to speak about the increasing role of the set of factors “ischemia + high CaSc” in the process
of selection for invasive diagnosis and subsequent revascularization.
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About the authors
- Leo A. Bockeria, Dr. Med. Sc., Professor, Academician of RAS and RAMS, Director; orcid.org/0000-0002-6180-2619
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Irina V. Shurupova, Dr. Med. Sc., Senior Researcher; orcid.org/0000-0002-2154-474Х;
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Irakliy P. Aslanidi, Dr. Med. Sc., Professor, Head of Department; orcid.org/0000-0001-6386-2378
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Anna A. Chernova, Postgraduate; orcid.org/0000-0003-3115-7409
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Tat'yana A. Trifonova, Cand. Med. Sc., Deputy Head of Department; orcid.org/0000-0002-9727-4213
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Diana M. Pursanova, Cand. Med. Sc., Researcher; orcid.org/0000-0002-1846-0115
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Andrey A. Kotlyarov, Dr. Med. Sc., Dean of the Medical Faculty of the Branch Obninsk Institute for Nuclear Power Engineering; orcid.org/0000-0003-2766-7895
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Aleksandr V. Perepelov, Cand. Med. Sc., Head of Chair; orcid.org/0000-0002-1818-1001
