Abstract
Purpose: to assess the physiological reserve according to the Edmonton frailty scale/index (EFI) before correction of valvular heart disease (VHD) in elderly patients (≥ 60 years) and patients up to 60 years (control group).
Material and methods. Two hundred and forty patients ≥ 60 years old (mean age 69.2 ±1.3 years) and 140 patients < 60 years old (mean age 58.1 ± 2.3 years) underwent correction of valvular heart defects ± coronary heart disease (VHD ± CAD). Before surgery, the patients underwent an assessment of the physiological status according to EFI. “Not frail” were 28.3% of the elderly and 51.5% of the control group, the majority (71.7%) of the elderly and 49.0% of patients up to 60 years before surgery were from “vulnerable” to “severe frail”. Thus, the average EFI score in the elderly before operations was 7.5 ±1.9 (“vulnerable”), and in the control group it was 4.7 ±2.8 (“not frail”) (p < 0.05). Every third elderly (34.6%) and 72.1% of patients in the control group underwent correction of the defect of two valves, 7% – up to 60 years.
Results. Non-lethal complications in the early postoperative period were noted in 42.9% of the elderly and in 20% of patients in the control group. Hospital mortality in ≥ 60 years is 7.9%, in up to 60 years is 3.6%. Predictors of postoperative complications in the elderly was EFI-status “mid, frail” → “severe frail” (p = 0.04), and in <60 years – “mid, frail” (p = 0.05).
Conclusion. A low physiological reserve (“painful” → “severe frail”) became a predictor of the development of complications in the early postoperative period in the elderly patients and in patients up to 60 years of age.
References
- Rolfson D., Sumit R., Tsuyuki R., Adeel T., Rockwood K. Validity and reliability of the Edmonton Frail. Scale. 2006; 35 (5): 526–9. DOI: 10.1093/ageing/afl041
- Fried L., Ferrucci L., Darer J., Williamson J., Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J. Gerontol. Biol. Sci. Med. Sci. 2004; 59 (3): 255–63. DOI: 10.1093/gerona/59.3.m255
- Rowe R., Iqbal J., Murali-Krishnan R., Sultan A., Orme R., Briffa N. et al. Role of frailty assessment in patients undergoing cardiac interventions. Open Heart. 2014; (1): е000033. DOI: 10.1136/openhrt-2013-00003
- Go A., Mozaffarian D., Roger V., Benjamin E., Berry J., Blaha M. et al. Subcommittee on behalf of the A.H.A.S.C. and S.S. Heart disease and stroke statistics – 2014 update: a report from the American Heart Association. Circulation. 2014; 129 (3): е28–92. DOI: 10.1161/01.cir.0000441139.02102.8
- Rolfson D., Montgomery C., Thanh N., Stelfox H., Norris C., Meyer S.R. et al. The impact of preoperative frailty on the clinical and cost outcomes of adult cardiac surgery in Alberta, Canada: A Cohort Study. CJC Open. 2020; 3 (1): 54–61. DOI: 10.1016/j.cjco.2020.09.009
- Henry L., Halpin L., Barnett S., Pritchard G., Sarin E., Speir A. Frailty in the cardiac surgical patient: Comparison of frailty tools and associated outcomes. Ann. Thorac. Surg. 2019; 108 (1): 16–22. DOI: 10.1016/j.athoracsur.2019.03.009
- Ushakov D.I., Peleshok A.S., Krivopalov V.A., Samedov Ya.S., Maliev Z.O. Mortality predictors in elderly cardiosurgical patients. Russian Journal of Thoracic and Cardiovascular Surgery. 2019; 61 (3): 197–201 (in Russ.). DOI: 10.24022/0236-2791-2019-61-3-197-201
- Choi J., Sunwoo L., Kim S., Kim K., Kim C. CHA2DS2-VASc Score, cerebral small vessel disease, and frailty in older patients with atrial fibrillation. Sci. Rep. 2020; 10 (1): 18765. DOI: 10.1038/s41598-020-75256-6
- Gugganig R., Aeschbacher S., Leong D., Meyre P., Blum S., Coslovsky M. et al. Frailty to predict unplanned hospitalization, stroke, bleeding and death in atrial fibrillation. Eur. Heart J. Qual. Care Clin. Outcomes. 2021; 7 (1): 42–51. DOI: 10.1093/ehjqcco/qcaa002
- Denfeld Q., Winters-Stone K., Mudd J., Gelow J., Kurdi S., Lee C. The prevalence of frailty in heart failure: A systematic review and meta-analysis. Int. J. Cardiol. 2017; 236: 283–89. DOI: 10.1016/j.ijcard.2017.01.153
- Matsue Y., Kamiya K., Saito H., Saito K., Ogasahara Y., Maekawa E. et al. Prevalence and prognosis impact of the coexistence of multiple frailty domains in elderly patients with heart failure: The FRAGILE-HF cohort study. Eur. J. Heart Fail. 2020; 22 (11): 2112–9. DOI: 10.1002/ejhf.1926
- Flaatten H., De Lange D., Morandi A., Andersen F., Artigas A., Bertolini G. et al. The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 60 years). Intensive Care Med. 2018; 43 (12): 1820–8. DOI: 10.1007/s00134-017-4940-8
- Baldwin M., Reid C., Westlake A., Rowe J., Granieri E., Wunsch H. et al. The feasibility of measuring frailty to predict disability and mortality in older medical intensive care unit survivors. Crit. Care. 2019; 29 (3): 401–8. DOI: 10.1016/j.jcrc.2013.12.019
- Brinkman S., de Jonge E., Abu-Hanna A., Arbous M., de Lange D., de Keizer N. Mortality after hospital discharge in ICU patients. Crit. Care Med. 2013; 41 (5): 1229–36. DOI: 10.1097/CCM.0b013e31827ca4e1
- Montgomery C., Stelfox H., Norris C., Rolfson D., Meyer S., Zibdawi M. et al. Association between preoperative frailty and outcomes among adults undergoing cardiac surgery: a prospective cohort study. CMAJ Open. 2021; 9 (3): E777–87. DOI: 10.9778/cmajo.20200034
- Wleklik M., Denfeld Q., Lisiak M., Czapla M., Kałużna-Oleksy M., Uchmanowicz I. Frailty syndrome in older adults with cardiovascular diseases – what do we know and what requires further research? Int. J. Environ. Res. Public Health. 2022; 19 (4): 2234. DOI: 10.3390/ijerph19042234
- Fattouch K., Corrao S., Augugliaro E., Minacapelli A., Nogara A., Zambelli G. et al. Сardiac surgery outcomes in patients with coronavirus disease 2019 (COVID-19): A case-series report. J. Thorac. Cardiovasc. Surg. 2022; 163 (3): 1085–92.e3. Published online 2020 Oct 22. DOI: 10.1016/j.jtcvs.2020.09.138
About the authors
- Tat’yana G. Nikitina, Dr. Med. Sci., Professor, Head of the Department; ORCID
- Dmitriy M. Pelekh, Cand. Med. Sci., Researcher, Cardiologist; ORCID
- Knar S. Gulyan, Cand. Med. Sci., Researcher, Cardiologist; ORCID
- Tat’yana Yu. Filippkina, Cand. Phys. Math. Sci., Analyst; ORCID
- Elena Z. Golukhova, Dr. Med. Sci., Professor, Academician of the Russian Academy of Sciences, Director of Center; ORCID