Аннотация
В НЦССХ им. А. Н. Бакулева РАМН впервые выполнено рандомизированное слепое плацебо-контролируемое исследование сочетанного применения ТМЛР и ангиогенного фактора a-ECGF у больных ИБС с конечной стадией поражения коронарных артерий. Проведенное исследование не дает основания утверждать, что одноразовое интрамиокардиальное введение ФР способствует усилению ангиогенеза.
Литература
1. Бокерия Л. А., Асланиди И. П., Беришвили И. И. и др. Оценка эффективности трансмиокардиальной лазерной реваскуляризации с помощью синхронизированной с электрокардиографией однофотонной эмиссионной компьютерной томографии и позитронной эмиссионной томографии // Бюлл. НЦССХ им. А. Н. Бакулева РАМН. - 2004. - Т. 5, № 4. - С. 105-115.
2. Вахромеева М. Н. Отбор больных и оценка результатов трансмиокардиальной лазерной реваскуляризации с помощью методов ядерной медицины: Дис. … д-ра мед. наук. - М., 2004.
3. Демидова О. А. Комбинированное лечение хронической ишемии нижних конечностей с использованием стимуляторов ангиогенеза: Дис. … канд. мед. наук. - М., 2005.
4. Лукашкин М. А. Экспериментальное обоснование и оценка первого опыта клинического применения терапевтического ангиогенеза с использованием генов VEGF и bFGF: Дис. … канд. мед. наук. - М., 2005.
5. Auerbach R., Kabail L., Knighton D., Folkman J. A simple procedure for the long-term cultivation of chicken embryo // Dev. Boil. - 1974. - Vol. 41. - P. 391-394.
6. Baffour R., Berman J., Garb J. L. et al. Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower limb ischemia: dose-response effect of basic fibroblast growth factor // J. Vasc. Surg. - 1992. - Vol. 16. - P. 181-191.
7. Bokeria L. A., Berishvili I. I., Sigaev U. I. et al. Is transmyocardial laser revascularization of benefit for patients with endstage coronary artery disease? // Interact. Card. Vasc. Thorac. Surg. - 2006. - Vol. 5. - P. S45.
8. Bokeria L. A., Golukhova E. Z., Eremeeva M. V., Berishvili I. I. Gene and cell therapy: alternative approach for myocardial revascularization // 6th Internat. Congress on Coronary Artery Disease. - 2005. - P. 383-386.
9. Dzau V. J., Mann M. J., Ehsan A., Gries D. P. Gene therapy and genomic strategies for cardiovascular surgery: the emergine field of surgiomics // J. Thorac. Cardiovasc. Surg. - 2001. - Vol. 121. - P. 206-216.
10. Fuchs S., Vodovotz Y., Leon M. B., Kornovski R. Laser myocardial revascularization enhances expression of angiogenic cytokines in a porcine model of chronic ischemia // J. Thorac. Coll. Cardiol. - 1999. - Vol.33. - P. 342А.
11. Geist A., Marx J., Muller S. et al. Combination of enoxeparin and fibroblast growth factor-1 in creases myocardial blood flogs and capillary density after myocardial infarction in rebbits // Eur. Surg. Research. - 2005. - Vol. 37. - P. 191-198.
12. Gospoderowitz D., Cheng J. Heparin protects basic and seidic FGF from inactivation // J. Cell. Physiol.- 1986. - Vol. 128. - P. 475-484.
13. Heilmann C. A. U., Attmann T., von Samson P. et al. Transmyocardial laser revascularization combined with vascular endothelial growth factor (VEGF 121) gene therapy for chronic myocardial ischemia - do the effects really add up? // Eur. J. Cardiothorac. Surg. - 2003. - Vol. 23. - P. 74-80.
14. Henry T. D., Abraham J. A. Review of preclinical and clinical results with vascular endothelial growth factors for therapeutic angiogenesis // Curr. Intervent. Cardiol. Rep. - 2000. - Vol. 2. - P. 228-241.
15. Horvath K. A., Chin E., Mann D. C. et al. Up-regulation of vascular endothelial growth factor m-RNA and angionesis after transmyocardial laser revascularization // Ann. Thorac. Surg. - 1999. - Vol. 68. - P. 825.
16. Hughes G. C., Biswas S. S., Yin B. et al. Therapeuthic angiogenesis in chronically ischemic porcine myocardium: comparative effects of bFGF and VEGF // Ibid. - 2004. - Vol. 77. - P. 812-818.
17. Hughes G. C., Kypson A. P., St. Luis J. D. et al. Induction of angiogenesis after TMR: a comparision of holmium:YAG, CO2, and eximer laser // Ibid. - 2000. - Vol. 70. - P. 504-509.
18. Khurana R., Simons M. Insights from angiogenesis trials using fibroblast growth factor for advanced arteriosclerotic disease // Trends Cardiovasc. Med. - 2003. - Vol. 13. - P. 116-122.
19. Klein S., Roghani M., Riftin D. B. Fibroblast growth faktors as angiogenesis factors: a new insight into their mechanism of action // Exs. - 1997. - Vol. 79. - P. 159-192.
20. Krabatsch T., Schaper F., Leder C. et al. Histological findings after transmyocardial laser revascularization // J. Card. Surg. - 1996. - Vol. 36. - P. 17-34.
21. Laham R. J., Rezaee M., Post M. et al. Intracoronary and inravenous administration of basic fibroblast growth factor // Drug. Metab. Dispos. - 1999. - Vol. 27. - P. 821-826.
22. Lansing A. M. Transmyocardial laser revascularization // Ann. Thorac. Surg. - 2000. - Vol. 70. - P. 1763
23. Losordo D. W., Vale P. R., Symes J. F. et al. Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of ph VEGF165 as sole therapy for myocardial ischemia // Circulation. - 1998. - Vol. 98. - P. 2800-2804.
24. Luo Z., Diaco M., Murohara T. et al. Vascular endothelial growth factor attenuates myocardial ischemia- reperfusion injury // Ann. Thorac. Surg. - 1997. - Vol. 64. - P. 993-998.
25. Lutter G., Attmann T., Heilmann C., Samson P. The combined use transmiocardial laser revascularization and fibroblastic growth factor enhances perfusion and regional contractility in chronically ischemic porcine hearts // Eur. J. Cardiothorac. Surg. - 2002. - Vol. 22. - P. 753-761.
26. Lutter G., Martin J., von Samson P. et al. Microperfusion enhancement after TMLR in chronically ischemic porcine hearts // Cardiovasc. Surg. - 2001. - Vol. 9. - P. 281-291
27. Lutter G., Schwarzkopf J., Lutz C. et al. Histologic findings of transmyocardial laser channels after 2 h // Ann. Thorac. Surg. - 1998. - Vol. 65. - P. 1437-1439.
28. Mueller X. M., Tevaearai H. T., Genton C. Y. et al. Are there vascular density gradients along myocardial laser channels? // Ibid. - 1999. - Vol. 68. - P. 125-130.
29. Post M. J., Simons M. The rational phase of therapeutic angiogenesis // Minerva Cardioangiol. - 2003. - Vol. 51. - P. 421-432.
30. Sauter A., Lambert K., Rupf A. et al. Three-step purification method of large quantities of human recombinant alpha endothelial cellular growth factor for clinical use // Int. J. Mol. Med. - 2007. - Vol. 19, № 1. - P. 97-103.
31. Sayeed-Shah U., Mann M. J., Martin J. еt al. Complete reversal of ischemic wall motion abnormalities by combined use of gene therapy with trasmyocardial laser revascularization // J. Thorac. Cardiovasc. Surg. - 1998. - Vol. 116. - P. 763-769.
32. Schaper W., Sharma H. S., Quinkler W. et al. Molecular biologic concepts of coronary anastomoses // J. Аmer. Coll. Cardiol. - 1990.
33. Selke F. W., Ruel M. Vascular growth factor and angiogenesis in cardiac surgery // Ann. Thorac. Surg. - 2003. - Vol. 75. - P. S685-690.
34. Shou M., Thirumutri V., Rajanogagam S. et al. Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels // J. Amer. Coll. Cardiol. - 1997. - Vol. 29. - P. 1102-1106.
35. Shumacher B., von Specht B.-U., Heberstroh J., Pecher P. The stimulation of neo-angiogenesis in the ischemic heart by the human growth factors FGF // J. Cardiovasc. Surg. - 1998. - Vol. 39. - P. 445-453.
36. Shumacher B., Pecher P., von Specht B.-U., Stregman T. Induction of neo-angiogenesis in ischemic myocardium by human growth factors: first clinical results of a new treatment of coronary disease // Circulation. - 1998. - Vol. 97, № 7. - P. 645-650.
37. Sommer A., Brewer M., Thompson R. et al. Human basic fibroblast growth factors: nucleotide gequence, genomic organization and expression in mammalian cells // J. Cold. Spring. Harb. Qant. Biol. - 1986. - Vol. 51 (Part 1). - P. 657-668.
38. Takeshita S., Zheng L. P., Brogi E. et al. Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model // J. Clin. Invest. - 1994. - Vol. 93. - P. 662-670.
39. Vale P. R., Losordo D. W., Milliken C. E. et al. Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia // Circulation. - 2001. - Vol. 103. - P. 2138-2143.
40. Wilting J., Christ B., Bokeloh M. A modified chorioallantoic membrane (CAM) assay for gualitative and guantitative study of growth factors // Anat. Embryol. - 1991. - Vol. 183. - P. 259-271
41. Yamamoto N., Kohmoto T., Roethy W. et al. Histologic evidence basic fibroblast growth factor enhances the angiogenic effects of transmyocardial laser revascularization // Basic. Res. Cardiol. - 2000. - Vol. 95, № 1. - P. 55-63.
